Omission of Axillary Lymph Node Dissection in Patients with pT0-2 ER+/HER2− Breast Cancer with 3–5 Positive Lymph Nodes Undergoing Adjuvant Systemic Therapy and Radiation Does Not Impact Overall Survival: A National Cancer Database Analysis
National rates for ALND decreased in patients with 3-5 positive LNs over the last decade. There was no difference in OS with omission of ALND in patients with ER+/HER2- breast cancer with 3-5 positive LNs, supporting further studies to evaluate deescalation of axillary surgery in this population.
Authors
- Veronica Jones (ORCID: https://orcid.org/0000-0003-2084-6815)
- Jamie Rand
- Katherine Schulz-Costello
- Natalie Johnson (ORCID: https://orcid.org/0000-0001-6676-5266)
- Peter Wu (ORCID: https://orcid.org/0000-0001-6503-3936)
- Annie Tang (ORCID: https://orcid.org/0000-0001-6974-4356)
- José A. Bazan (ORCID: https://orcid.org/0000-0002-8405-7156)
- Preeti Farmah
Institutions
- City of Hope (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1245/s10434-025-18546-5
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00