Pediatric respiratory co-infection and immunologic response: peds recon study protocol

Acute viral respiratory infections are the most common cause of childhood morbidity and mortality; however, they are frequently non-medically attended, leaving critical gaps in our understanding. Co-infections with respiratory viruses such as SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) may alter immune responses, but their impact on long-term immunity remains poorly understood. Understanding age-dependent patterns of respiratory viral infections and co-infections will provide critical insights into immune development and potential vulnerabilities in pediatric populations. This study aims to define age-based differences in immunity in the respiratory track in response to respiratory viral pathogens and examine the impact of co-infection on immune regulation.