Differences in antihypertensive drug blood levels in patients with hypertension (DECISION): a prospective study comparing pharmacokinetics and pharmacodynamics of perindopril in younger and older patients
Older adults exhibited higher perindoprilat exposure than younger adults, alongside an exploratory, nonsignificant trend toward greater systolic BP reduction. Given the limited sample size, no causal inference can be drawn from our data; nevertheless, these findings support consideration of age-related factors and individualized dosing in hypertension management.
Authors
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Dennis A. Hesselink (ORCID: https://orcid.org/0000-0003-1871-1962)
- Arend F. L. Schinkel (ORCID: https://orcid.org/0000-0002-6424-0754)
- Soma Bahmany (ORCID: https://orcid.org/0000-0002-0370-0614)
- Jorie Versmissen (ORCID: https://orcid.org/0000-0003-0674-7765)
- Tjebbe W. Galema (ORCID: https://orcid.org/0000-0002-3041-1703)
- Melvin Lafeber (ORCID: https://orcid.org/0000-0001-7061-6415)
- Wim J. R. Rietdijk (ORCID: https://orcid.org/0000-0002-2622-7321)
- Laura Peeters (ORCID: https://orcid.org/0000-0002-6148-9714)
- Olivier C. Manintveld (ORCID: https://orcid.org/0000-0002-2202-7314)
- Dimokrat Hassan (ORCID: https://orcid.org/0000-0002-5143-6096)
- Bart van Domburg
- Sebastiaan D. T. Sassen (ORCID: https://orcid.org/0000-0002-4525-638X)
- Jeroen B. van der Net
- Talip Tumkaya
Institutions
- Albert Schweitzer Hospital (GA)
- Erasmus MC (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Maasstad Ziekenhuis (NL)
- Lely (Netherlands) (NL)
- Albert Schweitzer Klinik (AT)
- Klinik Sonnenhof (CH)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Blood Pressure
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1080/08037051.2025.2580368
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00