Dapsone use in dermatology: indication, efficacy and tolerability experience of a UK tertiary dermatology department

Dapsone has been a quick and affordable treatment option for a diverse range of dermatological pathologies. Although licensed for the management of leprosy and dermatitis herpetiformis, its uses expand to a range of neutrophil- and eosinophil-driven pathologies. This retrospective study examined the use of dapsone at a large tertiary dermatology department in the UK serving a diverse population. In our report, we assess indications for use and treatment efficacy, and provide 3-year follow-up data on clinical outcomes and adverse events, and their frequency. These data demonstrate the unpredictable efficacy of dapsone, and allow dermatologists to better inform their patients regarding possible treatment success with dapsone, as well as to counsel patients regarding the frequency and range of possible adverse events.