Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
We investigated whether environmentally driven factors contribute to EOCRC. We observed accelerated epigenetic aging in EOCRC and epigenetic changes associated with chronic inflammation. Tumor immune cell abundances correlated more strongly with microbes in EOCRC than in AOCRC. These data suggest a dysregulation of the immune response in EOCRC, driving chronic inflammation and tissue aging.
Authors
- Malvenderjit S. Jagjit Singh (ORCID: https://orcid.org/0000-0001-8198-9153)
- Lary A. Robinson (ORCID: https://orcid.org/0000-0003-4579-0141)
- Afaf E.G. Osman (ORCID: https://orcid.org/0000-0002-3688-4683)
- Gregory Riedlinger (ORCID: https://orcid.org/0000-0001-5690-7777)
- Eric A. Singer (ORCID: https://orcid.org/0000-0003-3991-0696)
- Bryan P. Schneider (ORCID: https://orcid.org/0000-0003-1868-7739)
- Rebecca D. Dodd (ORCID: https://orcid.org/0000-0001-7295-1882)
- Xiaokui Molly Mo (ORCID: https://orcid.org/0000-0002-9797-2687)
- Cornelia M. Ulrich (ORCID: https://orcid.org/0000-0001-7641-059X)
- Aik Choon Tan (ORCID: https://orcid.org/0000-0003-2955-8369)
- Ahmad A. Tarhini (ORCID: https://orcid.org/0000-0002-3193-9702)
- Qin Ma (ORCID: https://orcid.org/0000-0002-3264-8392)
- Rebecca Hoyd (ORCID: https://orcid.org/0000-0003-1210-4491)
- Jiangjiang Zhu (ORCID: https://orcid.org/0000-0002-4548-8949)
- Jane C. Figueiredo (ORCID: https://orcid.org/0000-0001-8040-3341)
- YunZhou Liu (ORCID: https://orcid.org/0000-0002-9892-2438)
- Gabriel Tinoco (ORCID: https://orcid.org/0000-0002-2565-6124)
- Daniel Spakowicz (ORCID: https://orcid.org/0000-0003-2314-6435)
- Sheetal Hardikar (ORCID: https://orcid.org/0000-0003-0292-6168)
- Martin D. McCarter (ORCID: https://orcid.org/0000-0001-8174-1713)
- Matthew F. Kalady
- Yousef Zakharia (ORCID: https://orcid.org/0000-0001-9480-2626)
- Frances Di Clemente (ORCID: https://orcid.org/0009-0009-2019-1274)
- Ning Jin (ORCID: https://orcid.org/0000-0002-6689-4671)
- Anjun Ma (ORCID: https://orcid.org/0000-0001-6269-398X)
- Nicholas Denko (ORCID: https://orcid.org/0000-0001-6875-734X)
- Carlos H.F. Chan (ORCID: https://orcid.org/0000-0003-3656-2470)
- Michelle L. Churchman (ORCID: https://orcid.org/0000-0002-6560-1056)
- Daniel W. Rosenberg (ORCID: https://orcid.org/0000-0003-2897-2613)
- Naomi Fei (ORCID: https://orcid.org/0000-0001-9278-3521)
- Dennis J. Grencewicz (ORCID: https://orcid.org/0000-0002-6322-2853)
- Ayse S. Yilmaz (ORCID: https://orcid.org/0000-0002-2954-0305)
- Islam Eljilany (ORCID: https://orcid.org/0000-0001-6387-5419)
- Caroline E. Wheeler (ORCID: https://orcid.org/0000-0002-3374-4909)
- John D. Carpten (ORCID: https://orcid.org/0000-0002-6862-2821)
- Alexandra P. Ikeguchi (ORCID: https://orcid.org/0000-0002-4448-9755)
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Southern California (US)
- University of Iowa (US)
- Cedars-Sinai Medical Center (US)
- Indiana University Health (US)
- Hudson Institute (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- University of Iowa Hospitals and Clinics (US)
- The Ohio State University Wexner Medical Center (US)
- Moffitt Cancer Center (US)
- Indiana Cancer Consortium (US)
- Southern California Clinical and Translational Science Institute (US)
- Indiana University Bloomington (US)
- Oklahoma State University Oklahoma City (US)
- Rutgers Cancer Institute (US)
- University of Oklahoma Health Sciences Center (US)
- University of Colorado Anschutz Medical Campus (US)
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- UConn Health (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0177
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Amgen
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Sanofi
- Alpha Omega Alpha Honor Medical Society
- Ohio State University
- University of Utah
- Regeneron Pharmaceuticals
- Exelixis
- Huntsman Cancer Institute
- Pelotonia
- Eisai
- Astellas Pharma
- National Institutes of Health
- Genentech
- EMD Serono
- Foundation Medicine
- Janssen Research and Development
- National Center for Advancing Translational Sciences