Chromosomal Instability in Mouse-Induced Pluripotent Stem Cells: Insights into X and Y Aneuploidies
Our findings demonstrate that sex chromosome instability occurs in mouse iPS cells, as previously reported in mouse ES cells, suggesting a conserved phenomenon across pluripotent stem cell types. Importantly, the presence of multiple X chromosomes in the pluripotent state appears to contribute to this instability. Further studies are required to elucidate the underlying molecular mechanisms.
Authors
- Maurizio Zuccotti (ORCID: https://orcid.org/0000-0003-4648-0663)
- Marianna Paulis (ORCID: https://orcid.org/0000-0001-7803-9982)
- Paolo Vezzoni (ORCID: https://orcid.org/0000-0002-6382-3923)
- Paola Rebuzzini (ORCID: https://orcid.org/0000-0003-3761-6143)
- Silvia Garagna (ORCID: https://orcid.org/0000-0003-0803-2405)
- Lorenzo Fassina (ORCID: https://orcid.org/0000-0002-5587-4632)
- S. P. Lucia (ORCID: https://orcid.org/0000-0003-3368-2135)
Institutions
- University of Pavia (IT)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Cytogenetic and Genome Research
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1159/000549096
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00