The genetic lottery goes to school: Better schools compensate for the effects of students’ genetic differences

In this paper, we investigate whether better schools can compensate for the effects of children's genetic differences. To this end, we combine data from the Norwegian Mother, Father, and Child Cohort Study (MoBa) with Norwegian register data to estimate the interaction between measures of children's predisposition to education and school quality. We use MoBa's genetic data to compute polygenic indices for educational attainment (<i>PGI<sup>EA</sup></i>). Importantly, MoBa includes genetic data on mother-father-child trios, allowing us to identify causal genetic effects using within-family variation. We calculate school value-added measures from Norwegian register data, allowing us to causally estimate school quality effects. Leveraging the advantages of both data sources, we provide a causally identified study of gene-environment interactions in the school context. We find evidence for substitutability of <i>PGI<sup>EA</sup></i> and school quality in reading but not numeracy: A 1 SD increase of school quality decreases the impact of a 1 SD increase of <i>PGI<sup>EA</sup></i> on reading test scores by 6%. The substitutability arises through gains of students at the lower end of the <i>PGI<sup>EA</sup></i> distribution. This suggests that investments in school quality may help reduce educational inequalities arising from genetic differences between students.

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Publication Details

Journal
Proceedings of the National Academy of Sciences
Published
2025-10-24
DOI
https://doi.org/10.1073/pnas.2511715122
Primary Topic
School Choice and Performance
Type
article
Field-Weighted Citation Impact
0.00

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article

The genetic lottery goes to school: Better schools compensate for the effects of students’ genetic differences

Nicolai T. Borgen, Rosa Cheesman, Astrid Marie Jorde Sandsør, Paul Hufe
Proceedings of the National Academy of Sciences
School Choice and Performance
article

The genetic lottery goes to school: Better schools compensate for the effects of students’ genetic differences

Nicolai T. Borgen, Rosa Cheesman, Astrid Marie Jorde Sandsør, Paul Hufe
article en

Abstract

In this paper, we investigate whether better schools can compensate for the effects of children's genetic differences. To this end, we combine data from the Norwegian Mother, Father, and Child Cohort Study (MoBa) with Norwegian register data to estimate the interaction between measures of children's predisposition to education and school quality. We use MoBa's genetic data to compute polygenic indices for educational attainment (<i>PGI<sup>EA</sup></i>). Importantly, MoBa includes genetic data on mother-father-child trios, allowing us to identify causal genetic effects using within-family variation. We calculate school value-added measures from Norwegian register data, allowing us to causally estimate school quality effects. Leveraging the advantages of both data sources, we provide a causally identified study of gene-environment interactions in the school context. We find evidence for substitutability of <i>PGI<sup>EA</sup></i> and school quality in reading but not numeracy: A 1 SD increase of school quality decreases the impact of a 1 SD increase of <i>PGI<sup>EA</sup></i> on reading test scores by 6%. The substitutability arises through gains of students at the lower end of the <i>PGI<sup>EA</sup></i> distribution. This suggests that investments in school quality may help reduce educational inequalities arising from genetic differences between students.

Proceedings of the National Academy of SciencesVol. 122(43)
Norwegian Institute of Public Health (NO), University of Oslo (NO), University of Bristol (GB), Equality Now (US)
Aarhus Universitet, University of Bristol, Universitetet i Oslo, Universität Stuttgart
Openalex Percentile: Top 67%
School Choice and Performance
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The genetic lottery goes to school: Better schools compensate for the effects of students’ genetic differences — Nicolai T. Borgen, Rosa Cheesman, et al. · Proceedings of the National Academy of Sciences (2025) | TGRS Research Map | TGRS