Exploring the Association Between Per‐ and Polyfluoroalkyl Substances Exposure and the Risk of Stroke: A Systematic Investigation Using NHANES Data Analysis, Network Toxicology and Molecular Docking Approaches
This study identified a positive association between PFOS exposure and stroke risk, suggesting that the PI3K/AKT signaling pathway, along with its key effector molecule AKT1, may play a crucial role in mediating PFOS-induced stroke, thereby offering a theoretical foundation for the prevention and management of PFOS-associated stroke.
Authors
- Yayun Weng (ORCID: https://orcid.org/0000-0002-2286-3400)
- Mingjie Tang
- Xingyi He (ORCID: https://orcid.org/0000-0003-4223-0800)
- Shipeng Zhang (ORCID: https://orcid.org/0000-0002-9462-2841)
- Xiaoyu Zhu (ORCID: https://orcid.org/0000-0003-3333-689X)
- Qinwei Fu (ORCID: https://orcid.org/0000-0002-2383-9146)
- Enjie Tang
- Ling Li (ORCID: https://orcid.org/0000-0002-0087-3034)
- Man Lu (ORCID: https://orcid.org/0009-0005-8404-1073)
- Zhihui Jin
- Lu Yan (ORCID: https://orcid.org/0000-0003-4924-1895)
- Wenshan Li (ORCID: https://orcid.org/0000-0002-7968-2678)
- Yinghong Li (ORCID: https://orcid.org/0000-0003-0733-1710)
- Hanyu Wang (ORCID: https://orcid.org/0000-0001-9909-2029)
- Yanjie Jiang
- Rui Fu (ORCID: https://orcid.org/0000-0001-8893-5924)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Hong Kong Polytechnic University (HK)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- 81th Hospital of PLA (CN)
- Impact (CA)
- Chengdu University of Traditional Chinese Medicine (CN)
- McMaster University (CA)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/brb3.71014
- Citations
- 1
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- National Natural Science Foundation of China