The Impact of varus and valgus alignment on knee cartilage quality assessed by magnetic resonance imaging: insights from the IMI-APPROACH cohort
Lower limb malalignment, particularly intra-articular malalignment, is associated with compartment-specific lower cartilage quality, as reflected by longer T2 values. Distinguishing between bony and intra-articular malalignment, rather than overall limb alignment, should be a focus of future studies on malalignment. Future research should explore whether constitutional malalignment and early cartilage alterations may trigger cartilage degeneration and KOA progression.
Authors
- F. Eckstein (ORCID: https://orcid.org/0000-0002-2014-8278)
- Moyo C. Kruyt (ORCID: https://orcid.org/0000-0002-5983-5251)
- Nienke van Egmond (ORCID: https://orcid.org/0000-0003-1294-8408)
- Eva Bax (ORCID: https://orcid.org/0000-0003-3892-6987)
- S.C. Mastbergen (ORCID: https://orcid.org/0000-0002-8825-6486)
- Ruurd J. A. Kuiper (ORCID: https://orcid.org/0000-0002-6511-3896)
- W. Wirth (ORCID: https://orcid.org/0000-0002-2297-8283)
- Frank W. Roemer (ORCID: https://orcid.org/0000-0001-9238-7350)
- Roel J.H. Custers (ORCID: https://orcid.org/0000-0001-5253-2883)
- Harrie Weinans (ORCID: https://orcid.org/0000-0002-2275-6170)
- Francis Bérenbaum (ORCID: https://orcid.org/0000-0001-8252-7815)
- Hassan Rayegan
- I.K. Haugen (ORCID: https://orcid.org/0000-0001-7810-2216)
- F.J. Blanco (ORCID: https://orcid.org/0000-0002-0964-9215)
- M. Kloppenburg (ORCID: https://orcid.org/0000-0002-9294-2307)
- J.H.T.C. van den Kerkhof
Institutions
- Inserm (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Sorbonne Université (FR)
- Universitätsklinikum Erlangen (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Diakonhjemmet Hospital (NO)
- Chondrometrics (Germany) (DE)
- Centre de Recherche Saint-Antoine (FR)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- The Knee
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1016/j.knee.2025.10.005
- Citations
- 1
- Primary Topic
- Total Knee Arthroplasty Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- European Federation of Pharmaceutical Industries and Associations
- European Commission