Identification of a distinctive gene signature associated with disease activity in granulomatous myositis
GM is transcriptomically characterized by a strong IFNγ signature and overexpression of proinflammatory cytokines, including IL1B, TNF and TGFB1. Additionally, it exhibits a unique transcriptomic profile, including CHIT1, which correlates with disease activity.
Authors
- María Casal-Domínguez (ORCID: https://orcid.org/0000-0002-3905-3922)
- Albert Selva-O’Callaghan
- Corinna Preuße (ORCID: https://orcid.org/0000-0002-5494-8150)
- Felix Kleefeld (ORCID: https://orcid.org/0000-0002-0643-7313)
- José C. Milisenda (ORCID: https://orcid.org/0000-0003-0151-7872)
- Iago Pinal‐Fernandez (ORCID: https://orcid.org/0000-0001-6338-9218)
- Teerin Liewluck (ORCID: https://orcid.org/0000-0002-0212-5697)
- Shamima Islam (ORCID: https://orcid.org/0000-0001-6946-0492)
- Faiza Naz
- Andrew Lee Mammen (ORCID: https://orcid.org/0000-0003-3732-3252)
- Udo Schneider (ORCID: https://orcid.org/0000-0002-9117-3307)
- Gustavo Gutierrez-Cruz
- Werner Stenzel (ORCID: https://orcid.org/0000-0002-1143-2103)
- Margherita Milone (ORCID: https://orcid.org/0000-0002-4338-9007)
- Nikolas Ruffer (ORCID: https://orcid.org/0000-0001-8394-969X)
- Katherine Pak
- Stefania Del Orso
- Travis B. Kinder (ORCID: https://orcid.org/0000-0003-4161-8213)
- Raphael A. Kirou (ORCID: https://orcid.org/0000-0001-6481-4810)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Universität Hamburg (DE)
- SUNY Downstate Health Sciences University (US)
- Johns Hopkins Medicine (US)
- WinnMed (US)
- Humboldt-Universität zu Berlin (DE)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- Vall d'Hebron Institut de Recerca (ES)
- University Medical Center Hamburg-Eppendorf (DE)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Mayo Clinic in Arizona (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Mayo Clinic in Florida (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-10-17
- DOI
- https://doi.org/10.1093/rheumatology/keaf543
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00