Postbiotics derived from recombinant lactic acid bacteria exhibit high IL6-binding capacity and suppress IL6-induced STAT3 signaling
The study demonstrates that functional non-viable bacterial cells can be derived from the recombinant <i>L. lactis</i> with therapeutic proteins displayed on their surface and provides a good foundations for further studies of their postbiotic potential in adjunctive therapy of inflammatory intestinal diseases.
Authors
- Špela Zupančič (ORCID: https://orcid.org/0000-0001-6532-5891)
- Abida Zahirović (ORCID: https://orcid.org/0000-0001-9262-7553)
- Slavko Kralj (ORCID: https://orcid.org/0000-0001-7855-4888)
- Aleš Berlec (ORCID: https://orcid.org/0000-0002-8095-6998)
- Luka Snoj (ORCID: https://orcid.org/0000-0003-3097-5928)
- Sebastjan Nemec
- Andraž Verdir
Institutions
- University of Ljubljana (SI)
- Jožef Stefan Institute (SI)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1657810
- Citations
- 1
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Javna Agencija za Raziskovalno Dejavnost RS