Anatomical–biochemical discordance and prognostic role of bone metastases in advanced MTC treated with [¹⁷⁷Lu]Lu-DOTA-TATE
PRRT with [¹⁷⁷Lu]Lu-DOTA-TATE is a well-tolerated treatment option for selected patients with advanced MTC, including those receiving first-line therapy and those with low SSTR expression. In our limited cohort, bone metastases were associated with shorter PFS, and discordant imaging/biochemical responses are common. Functional imaging-guided selection and individualized response assessment are essential for optimal management.
Authors
- Sait Sağer (ORCID: https://orcid.org/0000-0003-2013-5845)
- Kerim Sönmezoğlu (ORCID: https://orcid.org/0000-0003-1215-5184)
- Azizullah Nazari (ORCID: https://orcid.org/0000-0002-3052-9314)
- Seçkin Bilgiç (ORCID: https://orcid.org/0000-0002-3429-7549)
Institutions
- Tekirdağ Namık Kemal University (TR)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Istanbul University-Cerrahpaşa (TR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s12885-025-15101-z
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00