Targeting Wnt/β-catenin signaling enhances the efficacy of anti-CD38 immunotherapy in multiple myeloma
These findings demonstrated that targeting Wnt signaling enhances the efficacy of daratumumab and provide a strong rationale for combining daratumumab with Wnt-signaling inhibition as a therapeutic strategy in MM.
Authors
- Steven T. Pals (ORCID: https://orcid.org/0000-0002-1419-0939)
- Yunguang Chen
- Marcel Spaargaren (ORCID: https://orcid.org/0000-0002-3135-5109)
- Xiayi Zhang (ORCID: https://orcid.org/0000-0003-2237-214X)
- Haiying Hua (ORCID: https://orcid.org/0000-0002-7656-9880)
- Zemin Ren
- Michaela Gregorová (ORCID: https://orcid.org/0000-0003-1605-0558)
- Xiaowei Qi (ORCID: https://orcid.org/0000-0002-5876-4957)
- Heng Li (ORCID: https://orcid.org/0000-0002-3633-6679)
- Zhen Wang
- Xiaoyu Yu (ORCID: https://orcid.org/0000-0003-0549-9560)
- Long Ye
- Tingting Yang (ORCID: https://orcid.org/0000-0003-4272-2151)
Institutions
- Jiangnan University (CN)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1016/j.neo.2025.101242
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Jiangsu Provincial Department of Education