The Italian network for severe malaria treatment (NOMAL): epidemiology, clinical presentation, management and outcomes in a non-endemic setting
Severe malaria is a medical emergency that may result in death [1]. Prompt diagnosis and adequate treatment are essential for the successful clinical management and for reducing the risk of death [2]. Most of the current knowledge on severe malaria is based on observations and results of studies carried out in malaria endemic countries. However, such evidence may not be completely relevant to non-endemic settings [3]. Indeed, severe malaria in endemic countries with stable transmission occurs mainly in children under 5 years of age and in pregnant women while in older children and adults, although they can still suffer of uncomplicated malaria, severe disease is extremely rare thanks to the partial immunity they've acquired over years of exposure to infective bites. Such semi-immune status prevents the evolution of uncomplicated malaria towards severe disease.
Authors
- Giulia Bertoli (ORCID: https://orcid.org/0000-0003-4175-1620)
- Tommaso Ascoli Bartoli
- Spinello Antinori (ORCID: https://orcid.org/0000-0003-0569-9407)
- Gabriella d’Ettorre (ORCID: https://orcid.org/0000-0002-3571-5677)
- Assunta Navarra (ORCID: https://orcid.org/0000-0002-3662-4312)
- Enrico Girardi
- Roberto Cauda
- Umberto D’Alessandro (ORCID: https://orcid.org/0000-0001-6341-5009)
- Carlo Pallotto (ORCID: https://orcid.org/0000-0002-0355-2885)
- Gaetano Maffongelli (ORCID: https://orcid.org/0000-0001-7784-2511)
- Emanuele Nicastri (ORCID: https://orcid.org/0000-0002-5606-8712)
- Lina Rachele Tomasoni
- Alessandra D’Abramo (ORCID: https://orcid.org/0000-0002-5160-9743)
- Lorenzo Zammarchi (ORCID: https://orcid.org/0000-0003-0892-8404)
- Antonella Vulcano (ORCID: https://orcid.org/0000-0002-0023-9658)
- Andrea Angheben (ORCID: https://orcid.org/0000-0003-4545-8034)
- Giordano Madeddu (ORCID: https://orcid.org/0000-0001-6099-2273)
- Luciano Attard
- Angela Corpolongo
- Katleen de Gaetano Donati
Institutions
- University of Sassari (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Luigi Sacco Hospital (IT)
- Azienda Ospedaliera di Perugia (IT)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Ospedale Sacro Cuore Don Calabria (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Ospedale Santa Maria (IT)
- MRC Unit the Gambia (GM)
- Azienda USL di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASST Fatebenefratelli Sacco (IT)
- University of Florence (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Travel Medicine and Infectious Disease
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1016/j.tmaid.2025.102919
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00