Genomic landscape of endometrial polyps
Here, we have characterized the genomic landscape of endometrial polyps. We show that chromosomal alterations affecting HMGA1 and HMGA2 are a major underlying cause for polyp development. In addition, we present UBE2A as a novel candidate gene for human tumorigenesis. Our results contribute to a better understanding of endometrial polyp development and pave the way towards the development of targeted, non-invasive treatment options.
Authors
- Esa Pitkänen (ORCID: https://orcid.org/0000-0002-9818-6370)
- Ralf Bützow (ORCID: https://orcid.org/0000-0003-4366-5099)
- Pia Vahteristo (ORCID: https://orcid.org/0000-0002-4615-3825)
- Miika M. Mehine (ORCID: https://orcid.org/0000-0003-0443-0625)
- Sara Khamaiseh (ORCID: https://orcid.org/0000-0001-6868-2341)
- Nanna Sarvilinna (ORCID: https://orcid.org/0000-0001-7222-2540)
- Annukka Pasanen (ORCID: https://orcid.org/0000-0002-0079-9807)
- Terhi Ahvenainen (ORCID: https://orcid.org/0000-0001-9926-5452)
- Vilja Jokinen (ORCID: https://orcid.org/0000-0003-0387-6932)
- Siiri Reinikka (ORCID: https://orcid.org/0000-0002-3812-4418)
- Susanna Nousiainen (ORCID: https://orcid.org/0000-0002-3126-4629)
- Pernilla von Nandelstadh (ORCID: https://orcid.org/0000-0002-5796-2353)
Institutions
- University of Helsinki (FI)
- Helsinki Institute of Physics (FI)
- Helsinki University Hospital (FI)
- Institute for Molecular Medicine Finland (FI)
- Cancer Society of Finland (FI)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s13073-025-01556-z
- Citations
- 1
- Primary Topic
- Gynecological conditions and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- China Scholarship Council
- Biocenter Finland
- Helsinki Institute of Life Science, Helsingin Yliopisto