Computerized cognitive training enhances cognitive function in Alzheimer’s disease by downregulating Ruminococcus-TMAO pathway
A 24-week CCT program improves cognitive function in MCI and mild AD, potentially through downregulating the R.torques-TMAO pathway within the MGB axis. This pathway represents a promising novel target for multi-domain intervention in AD.
Authors
- Wuhan Yu (ORCID: https://orcid.org/0000-0002-2889-2704)
- Ziying Yang (ORCID: https://orcid.org/0000-0002-9606-4900)
- Jiani Wu (ORCID: https://orcid.org/0000-0001-7488-4222)
- Zhangjin Qin
- Yang Lü (ORCID: https://orcid.org/0000-0002-9425-2967)
- Jiaqi Song (ORCID: https://orcid.org/0009-0001-0948-0077)
- Fuxin Zhong (ORCID: https://orcid.org/0000-0001-8370-6639)
- Junjin Liu
- Dianxia Xing (ORCID: https://orcid.org/0000-0003-4969-8027)
- Lihua Chen (ORCID: https://orcid.org/0000-0002-0675-1425)
- Wenbo Zhang (ORCID: https://orcid.org/0000-0001-7071-5931)
- Xiaoqin Wang (ORCID: https://orcid.org/0000-0003-4404-0082)
- Xintong Liu (ORCID: https://orcid.org/0000-0002-5675-5168)
- Jiarui Liu (ORCID: https://orcid.org/0000-0003-1881-1971)
- Wenqi Lü (ORCID: https://orcid.org/0000-0003-4083-8257)
- Weihua Yu
- Chengcheng Huang (ORCID: https://orcid.org/0009-0000-2621-9076)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s12967-025-07209-4
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Chongqing Science and Technology Commission
- Sichuan University
- Centre Scientifique et Technique du Bâtiment
- University of California, San Diego
- West China Hospital, Sichuan University