Identification of Core Senescence‐Related Genes and Characterization of Comprehensive Immune Landscape in Intervertebral Disc Degeneration
CTGF may play a pivotal role in IVDD, advancing our understanding of disease pathogenesis and demonstrating potential as a diagnostic and therapeutic target. Notably, reduced immune cell infiltration in severe IVDD may stem from either activation of intrinsic repair mechanisms or an immune-exhausted state. Investigating dynamic alterations in immune cell populations during IVDD progression could elucidate the critical role of immunity in disease pathogenesis and inform novel strategies for diagnosis and therapeutic intervention.
Authors
- Yu Amanda Guo (ORCID: https://orcid.org/0000-0003-3478-7991)
- Andrew Z. Wang (ORCID: https://orcid.org/0000-0002-9781-4494)
- J.J. Wang (ORCID: https://orcid.org/0000-0002-8559-8114)
- Jiaqi Qin (ORCID: https://orcid.org/0000-0002-8722-6533)
- Zhe‐Xiong Lian (ORCID: https://orcid.org/0000-0002-9525-1421)
- Ye Wang (ORCID: https://orcid.org/0000-0001-6823-9040)
- Qiang Xu (ORCID: https://orcid.org/0009-0005-2926-2316)
- Ding Li
Institutions
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- International Journal of Genomics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/ijog/2521994
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wuxi Health and Family Planning Commission