Optimized Lipid Nanoparticle-Mediated mRNA Co-Delivery of SOX5/SOX9 Enables Synergistic Senescence Reversal for Osteoarthritis Therapy
This work provides an advanced, synergistic mRNA therapeutic approach employing optimized LNPs to alleviate chondrocyte senescence and stimulate cartilage regeneration, representing a promising strategy for OA intervention.
Authors
- Zhongyin Ji
- Shanni Li
- Mingyang Ma (ORCID: https://orcid.org/0000-0002-2137-9270)
- Wenwei Qian (ORCID: https://orcid.org/0000-0002-5941-9637)
- Yang Yu (ORCID: https://orcid.org/0000-0003-2559-4231)
- Sen Liu (ORCID: https://orcid.org/0000-0001-5182-7241)
- Hui Li (ORCID: https://orcid.org/0000-0002-7184-592X)
- Yiyang Du
- Hongjun Xu (ORCID: https://orcid.org/0000-0002-8828-1032)
- Zhaojing Yin
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Biocytogen (China) (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ijn.s544168
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00