Effect of Protease‐Treated Royal Jelly Extract on Facial Wrinkles: A Placebo‐Controlled, Double‐Blind, Parallel‐Group Study
This is the first study to demonstrate the wrinkle-improving effects of pRJ. Our results suggest that pRJ not only controls stratum corneum water content, dermal thickness, and bacterial microbiome, but also affects stem cell competition and mesenchymal stem cell activation. pRJ can reduce or eliminate certain skin concerns of women by improving age-related wrinkles.
Authors
- Sachie IKEGAMI
- Norihiro SHIGEMATSU
- Hideto Okamoto (ORCID: https://orcid.org/0000-0003-2904-4640)
- Akio Ohkuma (ORCID: https://orcid.org/0000-0003-3222-4650)
- Takashi Ito (ORCID: https://orcid.org/0000-0001-5105-3434)
- Nobuaki Okumura (ORCID: https://orcid.org/0000-0002-2997-7291)
- Kayo Kunimoto (ORCID: https://orcid.org/0000-0001-8102-1193)
- Masayuki Yagi (ORCID: https://orcid.org/0000-0001-6005-8632)
- Masatoshi Jinnin (ORCID: https://orcid.org/0000-0001-9230-6207)
- Chizuru Fujikura (ORCID: https://orcid.org/0000-0002-7277-9653)
- Ayanori Yamaki (ORCID: https://orcid.org/0000-0002-3843-4555)
- Hayate Itatani
Institutions
- Amada (Japan) (JP)
- Okayama University (JP)
- Wakayama Medical University (JP)
- Bee Research Institute (CZ)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1111/jocd.70503
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00