Combination of Serum Neurofilament Light Chain and Serum Cardiac Troponin T as Biomarkers Improves Diagnostic Accuracy in Amyotrophic Lateral Sclerosis
Although sNfL alone performs well in distinguishing ALS from healthy controls, repurposing cTnT for ALS provides additional value in discriminating ALS from disease controls. The combination of sNfL and cTnT improves diagnostic accuracy and may help identify prognostically distinct ALS subgroups. ANN NEUROL 2026;99:408-417.
Authors
- Patrick Weydt (ORCID: https://orcid.org/0000-0003-2344-5662)
- Sarah Bernsen (ORCID: https://orcid.org/0000-0001-7485-2626)
- Torsten Grehl (ORCID: https://orcid.org/0000-0002-0631-6976)
- Thomas Meyer (ORCID: https://orcid.org/0000-0003-3194-7347)
- Rachel Fabian
- Paula Lindenborn
- Huelya Nazlican
Institutions
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Humboldt-Universität zu Berlin (DE)
- Ambulatory Rehabilitation Center Berlin Adlershof (DE)
- Alfried Krupp Hospital (DE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1002/ana.78066
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78