Pilot Study: Endoscopic-assisted Plasma Radiofrequency Ablation: A Minimally Invasive Strategy for Extremity Lymphatic Malformations

The EPRA technique offers a promising therapeutic alternative that combines the precision of endoscopy with the targeted energy delivery of radiofrequency ablation, thereby minimizing collateral damage and reducing the risks associated with conventional sclerotherapy or open resection. This initial experience supports the feasibility and safety of EPRA for extremity LMs, particularly in anatomically complex or treatment-refractory cases, and provides a foundation for future studies with expanded patient cohorts and long-term outcomes.