A multilayer network analysis of cardiovascular–depression comorbidity reveals symptom-specific molecular biomarkers
This network-based analysis revealed symptom-specific biological pathways linking CVD and depression. The identified biomarkers may offer insights into shared mechanisms and support future prevention and treatment strategies for cardiometabolic-psychiatric comorbidity.
Authors
- Binisha H. Mishra (ORCID: https://orcid.org/0000-0002-5605-5196)
- Markus Juonala (ORCID: https://orcid.org/0000-0001-9498-364X)
- Jos A. Bosch (ORCID: https://orcid.org/0000-0001-7780-4806)
- Mika A. P. Kähönen (ORCID: https://orcid.org/0000-0002-4510-7341)
- Arja O. Rydin (ORCID: https://orcid.org/0000-0002-5525-3350)
- Pashupati P. Mishra (ORCID: https://orcid.org/0000-0001-5177-3431)
- Jie Li (ORCID: https://orcid.org/0000-0002-1006-9314)
- Reijo Laaksonen (ORCID: https://orcid.org/0000-0001-9888-4278)
- Rick Quax (ORCID: https://orcid.org/0000-0002-0299-0074)
- Terho Lehtimäki (ORCID: https://orcid.org/0000-0002-2555-4427)
- Cillian Hourican (ORCID: https://orcid.org/0009-0002-3161-0736)
- Stavroula C. Tassi (ORCID: https://orcid.org/0009-0002-5743-6895)
- Angela Koloi (ORCID: https://orcid.org/0009-0001-8197-3749)
- Liisa Keltikangas-Järvinen
- Olli T. Raitakari
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- Tampere University (FI)
- University of Patras (GR)
- University of Ioannina (GR)
- Turku University Hospital (FI)
- Zora Biosciences (Finland) (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Fimlab (Finland) (FI)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725102109
- Primary Topic
- Cardiac Health and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Cardiovascular Research
- Yrjö Jahnssonin Säätiö
- European Commission
- ZonMw
- Universiteit van Amsterdam
- Kela
- Suomen Kulttuurirahasto
- Jane ja Aatos Erkon Säätiö
- Juho Vainion Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Emil Aaltosen Säätiö
- Sydäntutkimussäätiö
- Tampereen Tuberkuloosisäätiö
- Diabetesliitto
- Paavo Nurmen Säätiö
- Tays
- Syöpäsäätiö