Pregnancy-Triggered Hereditary Thrombotic Thrombocytopenic Purpura: A Case Report

We report a case of hTTP caused by complex compound heterozygous gene mutations. Currently, pregnancy is the only trigger for the patient's illness. Timely identification, early differential diagnosis from obstetric complications, and active management are crucial for improving the pregnancy outcome of hTTP patients. We adopted a more conservative strategy of prophylactic plasma infusion during pregnancy and also achieved good maternal and fetal outcomes.

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Publication Details

Journal
International Journal of Women s Health
Published
2025-10-01
DOI
https://doi.org/10.2147/ijwh.s554825
Primary Topic
Complement system in diseases
Type
article
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article

Pregnancy-Triggered Hereditary Thrombotic Thrombocytopenic Purpura: A Case Report

Xing Xin, Zhiwei Zhang, Na Yu
International Journal of Women s Health
Complement system in diseases
article

Pregnancy-Triggered Hereditary Thrombotic Thrombocytopenic Purpura: A Case Report

Xing Xin, Zhiwei Zhang, Na Yu
article en

Abstract

We report a case of hTTP caused by complex compound heterozygous gene mutations. Currently, pregnancy is the only trigger for the patient's illness. Timely identification, early differential diagnosis from obstetric complications, and active management are crucial for improving the pregnancy outcome of hTTP patients. We adopted a more conservative strategy of prophylactic plasma infusion during pregnancy and also achieved good maternal and fetal outcomes.

International Journal of Women s HealthVol. Volume 17
Shandong Provincial Hospital (CN), Shandong Maternal and Child Health Hospital (CN), Shandong First Medical University (CN)
Openalex Percentile: Top 68%
Complement system in diseases
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