Peripheral blood DNA methylation changes are predictive of incident radiographic osteoarthritis development: Data and biospecimens from the osteoarthritis initiative
Blood-based DNA methylation models may predict incident knee OA in healthy individuals using a small set of CpG sites. Further work should focus on evaluating the pathophysiological role of DNA methylation in incident OA.
Authors
- G. Dyson (ORCID: https://orcid.org/0009-0009-9617-696X)
- Clinton A. Brawner (ORCID: https://orcid.org/0000-0002-1705-6620)
- Matlock A. Jeffries (ORCID: https://orcid.org/0000-0001-9516-4312)
- Aleksander Szymczak (ORCID: https://orcid.org/0000-0002-9028-8428)
- Padmaja Mehta-D’souza (ORCID: https://orcid.org/0009-0000-5568-8373)
- Montana Barrett (ORCID: https://orcid.org/0009-0006-1005-1401)
- Nicholas Hanebutt
Institutions
- Veterans Health Administration (US)
- Oklahoma Medical Research Foundation (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100692
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00