A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease
Longitudinal changes in tau-PET, plasma p-tau<sub>217</sub>, cortical thickness - but not amyloid-PET - effectively track cognitive decline. Cortical thickness may be confounded by pseudo-atrophy in anti-Aβ trials. Plasma p-tau<sub>217</sub> is a robust and cost-effective alternative to tau-PET as an AD-specific surrogate biomarker for monitoring cognitive changes.
Authors
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Anna Dewenter (ORCID: https://orcid.org/0000-0002-5636-196X)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Sebastian Niclas Roemer (ORCID: https://orcid.org/0000-0003-3423-457X)
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Zeyu Zhu (ORCID: https://orcid.org/0000-0003-0970-4832)
- Lukas Frontzkowski (ORCID: https://orcid.org/0000-0001-9321-956X)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70783
- Citations
- 1
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Alzheimer's Association