A systematic literature review and bayesian meta-analysis of oral vancomycin primary prophylaxis for <i>Clostridioides difficile</i> infection in stem cell transplant patients
Oral vancomycin primary prophylaxis prevented CDI in HSCT patients without significantly affecting secondary outcomes. However, after controlling for publication bias, these findings were no longer significant. Further studies are needed to provide stronger evidence for or against this intervention, assess long-term safety, and assess potential effects on antimicrobial resistance.
Authors
- Guillermo Rodríguez-Nava (ORCID: https://orcid.org/0000-0001-9826-7050)
- Evans M. Whitaker (ORCID: https://orcid.org/0000-0003-1326-4374)
- Jorge Salinas (ORCID: https://orcid.org/0000-0002-9193-820X)
- Mindy Marie Sampson (ORCID: https://orcid.org/0000-0001-5724-5875)
- Eugenia Miranti (ORCID: https://orcid.org/0000-0002-0654-8937)
- Sa Shen
- Wajeeha Tariq (ORCID: https://orcid.org/0000-0001-8387-4309)
- Alexandre Rodrigues Marra (ORCID: https://orcid.org/0000-0002-7577-7688)
- Andrew R. Rezvani (ORCID: https://orcid.org/0000-0002-1661-7334)
- Erika Paola Viana Cardenas (ORCID: https://orcid.org/0000-0002-6399-890X)
- Ami Siddharth Bhatt (ORCID: https://orcid.org/0000-0001-8099-2975)
- Mingjun Jiang (ORCID: https://orcid.org/0000-0001-8689-0662)
Institutions
- University of Iowa (US)
- Hospital Israelita Albert Einstein (BR)
- Stanford University (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10179
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00