Perampanel Regulates Neuroinflammation and Ferroptosis via Activating FSP1 Following Brain Ischemia
These findings demonstrate that perampanel mitigates post-ischemic brain injury by inhibiting neuroinflammation and neuronal ferroptosis via FSP1 activation. This study highlights FSP1 as a novel therapeutic target and positions perampanel as a promising candidate for ischemic stroke treatment, leveraging its established safety profile and clinical availability.
Authors
- Tao Wang (ORCID: https://orcid.org/0000-0003-2250-7569)
- Meimei Zhang (ORCID: https://orcid.org/0000-0001-9621-4879)
- Jian-Meng Lv
- Wei Li (ORCID: https://orcid.org/0000-0002-4731-3632)
- Xuan Wang (ORCID: https://orcid.org/0000-0003-0743-543X)
- Juan Liu (ORCID: https://orcid.org/0000-0002-8693-4271)
- Yajuan Pan
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s544785
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Shaanxi Province