Dupilumab-Induced Generalized Lichen Planus: A Case Report
A temporal correlation and Naranjo adverse drug reaction score of 8 indicated dupilumab as the trigger, likely via Th1/Th2 immune deviation. This first-documented paradoxical reaction underscores dupilumab's potential to trigger generalized LP through immune deviation.
Authors
- Baochen Zhu (ORCID: https://orcid.org/0000-0002-0536-6429)
- Yuan Zhai (ORCID: https://orcid.org/0000-0003-0485-4022)
- Chuang Zhang (ORCID: https://orcid.org/0000-0002-2241-5376)
- Hui-Shang Feng (ORCID: https://orcid.org/0009-0007-6710-6319)
- Yulin Jia (ORCID: https://orcid.org/0000-0002-1000-1117)
- Guo-Dong Hua
- Xiao-Ran Zheng
- Guilian Yang (ORCID: https://orcid.org/0000-0001-5224-1592)
- Wu Zhang (ORCID: https://orcid.org/0000-0002-7887-8345)
- Tai Zhang
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Xiyuan Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s561924
- Citations
- 1
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Beijing University of Chinese Medicine