Real-world Evidence on Baseline Characteristics and Treatment in Metastatic Hormone-sensitive Prostate Cancer: Findings from the PIONEER 2.0 Big Data Investigation Group
In this study of nearly 70 000 men with metastatic hormone-sensitive prostate cancer, doctors' treatment decisions were influenced strongly by patients' age and other health issues, highlighting a growing preference for combination therapies. The findings highlight the importance of real-world evidence, which captures diverse, often under-represented, patients to complement clinical trials and guide more inclusive, evidence-based care.
Authors
- Paweł Rajwa (ORCID: https://orcid.org/0000-0003-4073-6584)
- Peter Kraft
- Carl Steinbeißer (ORCID: https://orcid.org/0000-0003-1493-3277)
- Robert Snijder (ORCID: https://orcid.org/0000-0002-5495-8287)
- Mauro Gacci (ORCID: https://orcid.org/0000-0001-7877-221X)
- Susan Evans‐Axelsson (ORCID: https://orcid.org/0000-0002-4240-0550)
- Giorgio Gandaglia (ORCID: https://orcid.org/0000-0002-5052-721X)
- James T. Brash
- Juan Gómez Rivas (ORCID: https://orcid.org/0000-0002-0556-3035)
- Sebastiaan Remmers (ORCID: https://orcid.org/0000-0001-9530-6448)
- Katharina Beyer (ORCID: https://orcid.org/0000-0002-8450-8850)
- Alberto Briganti (ORCID: https://orcid.org/0000-0002-2178-0494)
- Ayman Hijazy (ORCID: https://orcid.org/0000-0002-0812-3377)
- Qi Feng (ORCID: https://orcid.org/0000-0003-4326-034X)
- Alex Qinyang Liu (ORCID: https://orcid.org/0000-0003-0302-0472)
- Asieh Golozar (ORCID: https://orcid.org/0000-0002-4243-155X)
- Veeru Kasivisvanathan (ORCID: https://orcid.org/0000-0002-0832-382X)
- Eleanor Davies (ORCID: https://orcid.org/0000-0001-8128-5404)
- Philip Cornford (ORCID: https://orcid.org/0000-0002-7146-9258)
- Bertrand De Meulder (ORCID: https://orcid.org/0000-0002-2108-7657)
- Muhammad Imran Omar (ORCID: https://orcid.org/0000-0002-1597-3126)
- Rossella Nicoletti (ORCID: https://orcid.org/0000-0001-6898-7698)
- Jesús Moreno Sierra (ORCID: https://orcid.org/0000-0001-6837-7718)
- Daniel Kotik
- Thomas A. Abbott
- James N’Dow
- Peter-Paul M. Willemse
- Artsiom Harbachou
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University College Hospital (GB)
- Centre National de la Recherche Scientifique (FR)
- Project Management Institute (US)
- Astellas Pharma (Japan) (JP)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- University of Aberdeen (GB)
- Kantonsspital St. Gallen (CH)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- Odyssey House (US)
- Hospital Clínico San Carlos (ES)
- University Medical Center Utrecht (NL)
- Comprehensive Cancer Center Vienna (AT)
- Oncode Institute (NL)
- Cancer Genomics Centre (NL)
- IRCCS Ospedale San Raffaele (IT)
- Center for Advanced Systems Understanding (DE)
- Postgraduate School of Molecular Medicine (PL)
- Erasmus MC Cancer Institute (NL)
- Astellas Pharma (United States) (US)
- European Institute for Systems Biology and Medicine
- University of Florence (IT)
- University College London (GB)
- Bayer (Germany) (DE)
- University of Brighton (GB)
- Medical University of Vienna (AT)
- University of Hong Kong (HK)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1016/j.euros.2025.09.010
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52