Isobutyric Acid Regulates Gelatinase Secretion by Human Periodontal Ligament Stem Cells Via NF-κB Signalling
This study revealed a direct interaction between the metabolite isobutyric acid and hPDLSCs through the regulation of the activity of gelatinases, which partially explains the degradation of periodontal tissue and resorption of alveolar bone.
Authors
- Qiang Guo (ORCID: https://orcid.org/0000-0002-3740-6624)
- Xiaoyao Fu
- Ying Tu (ORCID: https://orcid.org/0000-0001-7770-9876)
- Li Zhang
- Caixia Pi
- Mei-Ling Duan (ORCID: https://orcid.org/0000-0003-4206-1242)
- Yonglu Jia
- Haoran Chen (ORCID: https://orcid.org/0000-0002-8951-7254)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5717-471X)
- Chengcheng Liu (ORCID: https://orcid.org/0000-0001-9679-3428)
- Jing Xie
- Huiling Zheng
- Biao Ren (ORCID: https://orcid.org/0000-0003-4215-2873)
- Hui Cao (ORCID: https://orcid.org/0000-0002-6775-9287)
- Minglei Huang (ORCID: https://orcid.org/0000-0002-7187-371X)
- Xinjie Ning
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1016/j.identj.2025.103966
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00