Alpha-1 antitrypsin deficiency and granulomatosis with polyangiitis: a systematic review and meta-analysis
This meta-analysis reinforces the link between AATD and GPA, particularly in carriers of the Z-allele, supporting the role of PR3 dysregulation in GPA pathogenesis.
Authors
- Alan David Salama (ORCID: https://orcid.org/0000-0002-9255-9092)
- John Robert Hurst (ORCID: https://orcid.org/0000-0002-7246-6040)
- David A. Lomas (ORCID: https://orcid.org/0000-0003-2339-6979)
- Nina Heyer‐Chauhan (ORCID: https://orcid.org/0000-0002-3500-9174)
- Aileen Marshall (ORCID: https://orcid.org/0000-0003-3283-6315)
- Reem Alluhibi (ORCID: https://orcid.org/0009-0002-0308-3828)
- Shashank Baradwaaj
Institutions
- Royal Free London NHS Foundation Trust (GB)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- The Royal Free Hospital (GB)
- King Abdullah International Medical Research Center (SA)
- The London College (GB)
- University College London (GB)
Publication Details
- Journal
- European Respiratory Review
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1183/16000617.0088-2025
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00