APOE4-APP interactions exert early influences on cerebrovascular structure and function: implications for Alzheimer’s disease
These findings indicate that early vascular changes, driven by the interaction of <i>APP</i> and <i>APOE4</i>, may influence the progression of AD. Our work highlights the need to focus on the synergistic vascular actions of <i>APOE4</i> and <i>APP</i>, particularly at younger ages.
Authors
- Albert I. Chen (ORCID: https://orcid.org/0000-0001-5355-024X)
- Sok-Hong Kho
- Takaomi C. Saido (ORCID: https://orcid.org/0000-0003-1970-6903)
- Calvin Cheah
- Toh Hean Ch’ng (ORCID: https://orcid.org/0000-0002-7170-1512)
- George J. Augustine
- Judy Sng (ORCID: https://orcid.org/0000-0002-6740-6940)
- Lanboling Guo
- Takashi Saito (ORCID: https://orcid.org/0000-0001-9495-3547)
- Norliyana Zainolabidin
- Jessica Gaunt
- Alaric K. K. Yip (ORCID: https://orcid.org/0000-0001-9934-6914)
- Kah‐Leong Lim (ORCID: https://orcid.org/0000-0002-5440-2588)
- Yee Jie Yeap (ORCID: https://orcid.org/0000-0002-4511-9369)
- Hiroki Sasaguri (ORCID: https://orcid.org/0000-0003-2550-9156)
- Gavin S. Dawe (ORCID: https://orcid.org/0000-0001-6119-701X)
- Grace Lim (ORCID: https://orcid.org/0000-0001-8013-0080)
- Eyleen Lay Keow Goh
- Pawan Kumar (ORCID: https://orcid.org/0000-0003-2543-3147)
- Yun-An Lim
- Stephanie Claudine
Institutions
- Salk Institute for Biological Studies (US)
- Temasek Life Sciences Laboratory (SG)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- RIKEN Center for Brain Science (JP)
- Nagoya City University (JP)
- National Neuroscience Institute (SG)
- Scintillon Institute (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3389/fnins.2025.1629830
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00