Expression of G-quadruplex coordinates BRCA1, CDH1, and RASSF1 via DNA methylation in mouse breast cancer cells
Promoter G4 structures actively regulate gene expression by modulating de novo DNA methylation, suggesting that targeting G4s may represent a novel therapeutic strategy for breast cancer.
Authors
- Shuhui Yang (ORCID: https://orcid.org/0000-0002-8013-1873)
- LiMei Liu (ORCID: https://orcid.org/0000-0001-6857-9440)
- Yang Jiang (ORCID: https://orcid.org/0000-0002-5364-1421)
- Jin Zhang (ORCID: https://orcid.org/0000-0002-7464-2247)
- Zhuo Zhang (ORCID: https://orcid.org/0000-0002-0013-432X)
- Helin Wang (ORCID: https://orcid.org/0000-0002-7059-4217)
- Shuhan Dong
- Xiaoyan Zhan (ORCID: https://orcid.org/0000-0002-2446-5967)
- Wei Xia (ORCID: https://orcid.org/0000-0001-9597-7911)
- Xinchen Zhou (ORCID: https://orcid.org/0000-0002-7597-7604)
Institutions
- Beihua University (CN)
- Tianjin University of Traditional Chinese Medicine (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1080/17501911.2025.2577003
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00