Persimmon carotenoid extract rich in β‐cryptoxanthin improves glucose homeostasis and reduces liver damage in high‐fat‐diet‐induced type 2 diabetic and metabolic dysfunction‐associated steatotic liver disease mice
PSCE ameliorated HFD-induced metabolic dysfunction, inflammation and liver injury, suggesting persimmon byproducts represent a promising source of bioactive compounds for managing T2DM and MASLD. Further studies are needed to clarify the mechanistic and molecular role of β-CRX, the main persimmon carotenoid, in mediating these protective effects. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Authors
- Bryan Moreno‐Chamba (ORCID: https://orcid.org/0000-0002-4263-2239)
- Julio Salazar‐Bermeo (ORCID: https://orcid.org/0000-0002-8920-9817)
- Genoveva Berná (ORCID: https://orcid.org/0000-0001-8185-8428)
- Manuel Valero (ORCID: https://orcid.org/0000-0002-4966-9704)
- María‐Soledad Fernández‐Pachón (ORCID: https://orcid.org/0000-0002-9524-298X)
- Blanca Escudero‐López (ORCID: https://orcid.org/0000-0002-4964-1306)
- Domingo Saura (ORCID: https://orcid.org/0000-0003-4711-0744)
- Marı́a Concepción Martı́nez-Madrid (ORCID: https://orcid.org/0000-0003-3231-3995)
- Nuria Martí (ORCID: https://orcid.org/0000-0003-1820-9593)
- Franz Martı́n (ORCID: https://orcid.org/0000-0002-5745-8704)
- Antonio Cárdenas
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro Andaluz de Biología Molecular y Medicina Regenerativa (ES)
- Medical Research Network (US)
- Universitat Politècnica de València (ES)
- Universidad Pablo de Olavide (ES)
Publication Details
- Journal
- Journal of the Science of Food and Agriculture
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1002/jsfa.70276
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00