High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell

Collectively, these results demonstrate that high glucose promotes OGT-mediated O-GlcNAcylation of ACSL4, thereby stabilizing this enzyme and facilitating ferroptosis progression in DN.

Authors

Meiling Ye (ORCID: https://orcid.org/0009-0005-0166-0048)
Xinguo Ding
Zhisong Chen (ORCID: https://orcid.org/0000-0002-1525-4236)
Lina Liang
Jing Qin

Institutions

Xiamen Chang Gung Hospital (CN)

Publication Details

Journal: Autoimmunity
Published: 2025-10-24
DOI: https://doi.org/10.1080/08916934.2025.2576881
Citations: 1
Primary Topic: Ferroptosis and cancer prognosis
Type: article
Field-Weighted Citation Impact: 1.52

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article

High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell

Meiling Ye, Xinguo Ding, Zhisong Chen, Lina Liang et al.

Oct 24, 2025

1 citations

Autoimmunity

Ferroptosis and cancer prognosis

1.52

article

High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell

Meiling Ye, Xinguo Ding, Zhisong Chen, Lina Liang, Jing Qin

October 24, 2025article en

1 citations

Abstract

Collectively, these results demonstrate that high glucose promotes OGT-mediated O-GlcNAcylation of ACSL4, thereby stabilizing this enzyme and facilitating ferroptosis progression in DN.

AutoimmunityVol. 58(1)

Xiamen Chang Gung Hospital (CN)

Openalex Percentile: Top 13%

Ferroptosis and cancer prognosis

1.52

DOI Open Access PDF OpenAlex

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High glucose promotes O-GlcNAcylation of ACSL4 to induce ferroptosis of renal tubular epithelial cell — Meiling Ye, Xinguo Ding, et al. · Autoimmunity (2025) | TGRS Research Map | TGRS