FEV1 and Platelet Parameters in Diabetic Rural School Teachers

Introduction and Aim: Platelets play a crucial role in hemostasis. There are limited studies on altered platelet parameters associated with inflammation in respiratory disorders. FEV1 is widely used as an indicator of lung function. This study aims to investigate the relation between FEV1 and platelet parameters in diabetic rural school teachers for early detection of their respiratory illness. Materials and methods: This random study included 41 rural female diabetic school teachers. The study is approved by Institutional Ethics Committee of GSL Medical College and General Hospital, Rajahmundry. After informed, written consent FEV1 is recorded using portable spirometer. For platelet parameters, the blood samples are collected through venipuncture under aseptic conditions. Platelet parameters including PLT (Platelet count), MPV (Mean platelet volume), PDW-SD (Platelet distribution width-Standard deviation), PDW-VC (Platelet Distribution Width-Variation Coefficient), P-LCR (Platelet-Large Cell Ratio), P-LCC (Platelet-Large Cell Count) are analyzed using an automated analyzer. Correlation between variables is analyzed with Pearson correlation. Results: The mean age of participants is 39.61 ± 6.62 years with BMI of 26.70 ± 4.8 kg/m2. The mean FEV1 is1.622 ± 0.43 lit/min. FEV1 is negatively correlated with BMI (r=-0.420, p<0.01), while it is positive with platelet count (mean=337.65 ± 53.55; r=0.320, p=0.05). The negative correlation observed between FEV1 and other platelet parameters suggest their potential inverse relationship. Conclusion: In this study the decrease in FEV1with increased BMI shown that higher BMI is associated with reduced lung function. However, as platelets release Platelet Derived Growth Factor (PDGF) that can promote lung tissue repair and regeneration, the positive association with platelet count in this study signify the protection of lung parenchyma. Large sample size is warranted for the importance of managing both metabolic and platelet related factors in female diabetic rural teachers to mitigate the risk of respiratory complications.