Discovery of ultrasound-derived fat fraction as a non-invasive tool for MASLD diagnosis
Ultrasound testing for UDFF provides a simple and noninvasive clinical tool to quantify the extent of hepatic steatosis. The diagnostic efficacy of UDFF is superior to CAP. Notably, while UDFF shows strong agreement with MRI-PDFF overall, Bland-Altman analysis revealed a proportional bias, with UDFF tending to underestimate MRI-PDFF at higher fat content levels. Despite this limitation, UDFF demonstrates potential as a noninvasive alternative to MRI-PDFF for MASLD diagnosis.
Authors
- Chengxiao Yu (ORCID: https://orcid.org/0000-0002-6735-0027)
- Mengfan Jiao
- Qingling Chen (ORCID: https://orcid.org/0009-0008-0063-2952)
- Erfu Xie (ORCID: https://orcid.org/0000-0002-6787-7646)
- Zixing Dai
- Yuwen Li (ORCID: https://orcid.org/0009-0008-7673-3987)
- Tingting Ren (ORCID: https://orcid.org/0000-0003-4981-8922)
- Huiru Jin
- Longfeng Jiang (ORCID: https://orcid.org/0000-0001-8058-6838)
Institutions
- Nanjing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s40001-025-03229-4
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Government of Jiangsu Province