Mendelian randomization and single-cell analysis reveal novel genetic risk factors and cellular heterogeneity in glioblastoma
This study provides robust evidence for novel genetic risk factors in glioblastoma development and reveals the complex cellular landscape of the tumor microenvironment. The identified protective and risk genes offer potential targets for therapeutic intervention and biomarker development.
Authors
- Lianshu Ding
- Jun Li (ORCID: https://orcid.org/0000-0003-3971-2083)
- Jing Xu (ORCID: https://orcid.org/0009-0006-1869-4903)
- Jialuo Chen (ORCID: https://orcid.org/0000-0002-6258-5177)
Institutions
- Huaian First People’s Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1007/s12672-025-03808-1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00