HIF-1α mediated ferroptosis is a critical target for renal prognosis in septic shock rats receiving VA-ECMO support
This study reveals that timely VA-ECMO support in septic shock rats protects the kidneys by synergistically restoring macro-circulatory perfusion and optimizing oxygen delivery. The regulation of the HIF-1α-ferroptosis axis is established as a critical mechanistic component of this protection, with its activity being dependent on the oxygen content delivered by the VA-ECMO circuit.
Authors
- Mingru Zhang (ORCID: https://orcid.org/0000-0002-4514-9824)
- Shujie Yan (ORCID: https://orcid.org/0009-0007-6706-880X)
- Bingyang Ji (ORCID: https://orcid.org/0000-0002-1410-6901)
- Luyu Bian
- Jian Wang (ORCID: https://orcid.org/0000-0002-5335-8845)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7199-4784)
- Gang Liu (ORCID: https://orcid.org/0000-0002-3431-3270)
- Tianlong Wang (ORCID: https://orcid.org/0000-0002-3509-9480)
- Jieru Zhang (ORCID: https://orcid.org/0009-0000-5372-5177)
- Han Zhang (ORCID: https://orcid.org/0009-0004-2828-3804)
- Yuan Teng
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1097/js9.0000000000003623
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00