Development and Integration of a Molecularly Imprinted Determination Atenolol in Pharmaceutical Samples Based on Solid Phase Extraction

The current investigation aims to display that bulk polymerization of Atenolol (Ate) can synthesize and store molecular-imprinted polymers (MIP) at room temperature. It is indicated that such an environment has various advantages, including higher sensitivity, lower costs, higher stability, and longer life. To guarantee appropriate adsorption capacity, 0.99:6:20 mmol ratios of template, monomer, and cross-linking agents are employed for polymerization. To start the functional monomer styrene (C8H8) bonding Ethylene glycol dimethacrylate (EGDMA) C10H14O4, the researcher employed benzoyl peroxide (BPO). Accordingly, MIP is created for Atenolol (Ate-MIP), which can be detected for pharmaceuticals employing UV-visible spectrophotometry at 276 nm for drugs. Fourier-transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) were utilized. Large cavities appear due to the elution process’s application on the template (Ate) from the Ate-MIP. These cavities resulted from a porogenic mixture of solvents produced from methanol, chloroform, and acetic acid (70:20:10). The Langmuir isotherm model indicated that Ate-MIP has a maximum adsorption capacity of 2.9957 μmol/g, and the template to monomer ratio was 1:1. Molecular imprinted polymers (MIPs)-filled solid-phase extraction (SPE) syringe was used to selectively extract and pre-concentrate Ate from aqueous solutions and atenolol estimations.