Synthesis, Characterization, and Studying the Biological Activity, Thermal, and Physical Properties with the Evaluation of Pharmaceutical Release of New Derivatives from Polyvinylpyrrolidone

In this research drug polymers, have been prepared by substituting drugs to polymers backbone, which raised interest as a result of the benefits systems possesses, which includes the gradual release of the application of the drug, ease of application, delivery of the drugs in certain (specific) local, prolong the period of drug douse, reduce the potential and common side effects, and decrease the toxicity. This work included ring opening of PVP with ethylene glycol then substitution with different drugs (Salbutamol and Ribavirin, Phenylephrine, Theophylline, Sulfamethoxazole). All prepared drug polymers were identified by FT-IR,1H-NMR, and UV. Spectroscopes, thermal analysis such as TGA. The physical properties of all polymers were measured. The controlled release for all polymers was studied in different pH values at [30–40 °C]. The hydrolysis data showed that release rates are strongly dependent on the pH of the medium and temperature. We concluded that the drug polymers could enhance the solubility of drug carrier polymers in water, with desirable properties, slow-release, and prolonged activity. These four methods of advanced properties and bearing of the different bioactive units, and studying Molecular Docking.