Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling
This study identifies P. gingivalis as a tumor-associated bacterium that promotes CSCC metastasis through direct interaction between its fimbrial adhesin FimA and the host CD151/ITGB1 complex. This interaction activates JNK/paxillin signaling, induces cytoskeletal reorganization, and enhances the metastatic capacity of CSCC cells. Targeting this microbial-host interaction may provide a novel therapeutic intervention for P. gingivalis-driven CSCC metastasis.
Authors
- Wenjun Pan (ORCID: https://orcid.org/0009-0000-5592-6466)
- Xiuting Huang
- Huilong Nie (ORCID: https://orcid.org/0000-0002-2114-3372)
- Zhenqi Jiang (ORCID: https://orcid.org/0000-0002-2685-1327)
- Yujing Lin (ORCID: https://orcid.org/0000-0003-0129-0401)
- Xiaoyu Feng (ORCID: https://orcid.org/0000-0003-4317-6738)
- Huimin Lan
- Ling Yi (ORCID: https://orcid.org/0000-0001-5250-214X)
- Xian‐Tao Zeng (ORCID: https://orcid.org/0000-0003-1262-725X)
- Yuan Zhuang (ORCID: https://orcid.org/0000-0003-3377-9658)
- Guangxue Wang (ORCID: https://orcid.org/0009-0003-3920-7236)
- De Yun Wang (ORCID: https://orcid.org/0000-0002-0909-2963)
- Yuanyang Tan
- Yan Yan (ORCID: https://orcid.org/0000-0002-3968-1320)
- Liang Li (ORCID: https://orcid.org/0000-0003-1001-7837)
- Rui Wang (ORCID: https://orcid.org/0000-0003-1723-4746)
- Kefeng Li (ORCID: https://orcid.org/0000-0002-7233-4347)
- Jing Qu (ORCID: https://orcid.org/0000-0003-3476-5127)
- Yongkang Qiao (ORCID: https://orcid.org/0000-0002-1052-6722)
Institutions
- Beijing Institute of Technology (CN)
- Sun Yat-sen University (CN)
- National University of Singapore (SG)
- Beijing Normal University (CN)
- Southern University of Science and Technology (CN)
- Wuhan University (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Shanghai East Hospital (CN)
- National University Health System (SG)
- Macao Polytechnic University (MO)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s12967-025-06928-y
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Beijing Normal University
- Southern University of Science and Technology