SRSF1 is essential for pancreatic β-cell proliferation and the maintenance of glucose homeostasis in mice
SRSF1 is essential for β-cell proliferation and function through MYC-mediated pathways. Its deficiency disrupts β-cell homeostasis and contributes to metabolic dysfunction in mice, underscoring its importance in preserving functional β-cells and maintaining glucose balance.
Authors
- Yijun Lin (ORCID: https://orcid.org/0009-0004-6330-0593)
- Ying Feng (ORCID: https://orcid.org/0000-0001-9501-156X)
- Qian Peng (ORCID: https://orcid.org/0000-0003-3261-3330)
- Wenju Qian
- Zhiqin Xie (ORCID: https://orcid.org/0000-0002-3011-5031)
- Yan‐Zhi Gai
- Jiazheng Ye (ORCID: https://orcid.org/0009-0004-7604-3362)
- Xue You
Institutions
- First Affiliated Hospital of Xiamen University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- University of Chinese Academy of Sciences (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Metabolism
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1016/j.metabol.2025.156421
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00