Human dental pulp stem cell-derived mitochondria restore mitochondrial function and promote neuroregeneration in a cellular model of Parkinson’s disease
Mitochondria derived from hDPSCs can restore bioenergetic function, reduce oxidative stress, and promote structural and functional recovery in a PD cellular model. These findings highlight the foundational therapeutic potential of hDPSC-derived mitochondria as a regenerative approach for neurodegenerative diseases.
Authors
- Sujiwan Seubbuk Sangkhamanee (ORCID: https://orcid.org/0000-0002-8292-4252)
- Hathaitip Sritanaudomchai (ORCID: https://orcid.org/0000-0001-6171-3918)
- Tawepong Arayapisit (ORCID: https://orcid.org/0000-0002-9680-3347)
- Thanasup Gonmanee (ORCID: https://orcid.org/0000-0001-9108-6476)
- Permphan Dharmasaroja (ORCID: https://orcid.org/0000-0003-1557-8940)
- Kawinthra Khwanraj
- Satjapot Manprasong
- Pijitra Petcharat
Institutions
- Mahidol University (TH)
- Ramathibodi Hospital (TH)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1186/s13287-025-04702-x
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00