Endoluminal Functional Lumen Imaging Probe in the Functional Assessment of Pyloric Sphincter in Gastroparesis: A Systematic Review With Meta‐Analysis of Normative Values
EndoFLIP provides reproducible pyloric functional metrics in gastroparesis. DI and CSA, particularly at 40-50 mL distension, are the most reliable parameters, improving consistently after pylorus-targeted therapies and reflecting clinical benefit. A DI of < 7-10 mm<sup>2</sup>/mmHg may represent a pragmatic threshold for impaired distensibility and a good target for treatment response.
Authors
- Edoardo Vespa (ORCID: https://orcid.org/0000-0002-5573-447X)
- Niek Warringa (ORCID: https://orcid.org/0000-0002-6321-9021)
- Francesco Vito Mandarino (ORCID: https://orcid.org/0000-0002-9931-7221)
- Albert Jan Bredenoord (ORCID: https://orcid.org/0000-0001-5918-2062)
- Gwen Masclee (ORCID: https://orcid.org/0000-0002-2839-027X)
- Silvio Danese (ORCID: https://orcid.org/0000-0001-7341-1351)
- Sandro Passaretti
- Alberto Barchi (ORCID: https://orcid.org/0000-0002-0179-8929)
- Milli Gupta
Institutions
- Vita-Salute San Raffaele University (IT)
- University of Calgary (CA)
- Amsterdam Neuroscience (NL)
- IRCCS Ospedale San Raffaele (IT)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1111/nmo.70187
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- Universiteit van Amsterdam