Evaluation of the antileishmanial effects and the mode of action of the natural topoisomerase inhibitor shikonin in <i>Leishmania donovani</i>
Targeting the Leishmania parasite Topoisomerase with the natural naphthoquinone SKN inhibits parasite proliferation. SKN generates oxidative stress, leading to mitochondrial dysfunction, elevation of cytosolic calcium, and nuclear damage resulting in apoptotic cell death.
Authors
- Swetapadma Majhi (ORCID: https://orcid.org/0000-0002-6482-0353)
- Rahul Kumar Jaiswal (ORCID: https://orcid.org/0000-0003-3800-7235)
- Mohammad Imran Siddiqi (ORCID: https://orcid.org/0000-0001-5655-5484)
- Kalyan Mitra (ORCID: https://orcid.org/0000-0002-7252-1716)
- Juhi Sharma (ORCID: https://orcid.org/0000-0002-9820-3820)
- Achchhe Lal Vishwakarma
Institutions
- Central Drug Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1093/jambio/lxaf260
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00