Risk of Esophageal and Gastric Cancer by Histologic Subtype in Steatotic Liver Disease: A UK Biobank Study
Upper GI cancer risk in SLD patients is significantly modified by alcohol consumption, with combined metabolic dysfunction and alcohol exposure conferring the highest risks for esophageal adenocarcinoma and intestinal-type gastric cancer. Clinically, these findings suggest that SLD patients with any level of alcohol consumption require heightened cancer surveillance. Even minimal alcohol intake substantially increases cancer risk in metabolically compromised individuals, supporting alcohol reduction as a key preventive strategy.
Authors
- Ji Won Han (ORCID: https://orcid.org/0000-0003-1456-1450)
- Dong Hoon Kang (ORCID: https://orcid.org/0000-0002-7278-2174)
- Kenneth Muir (ORCID: https://orcid.org/0000-0001-6429-988X)
- Artitaya Lophatananon (ORCID: https://orcid.org/0000-0003-0550-4657)
- Jongin Lee (ORCID: https://orcid.org/0000-0003-4337-8444)
Institutions
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-24
- DOI
- https://doi.org/10.3390/cancers17213416
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00