A multi-omics approach uncovers causality of <i>IL6R</i> on endotypes of subclinical carotid atherosclerosis and the possible role of the IL6R/OSMR pathway
Rs2228145A/C associated with endotype 4 clinical and molecular characteristics and amplified the MI risk in individuals assigned to endotype 4. These effects appeared to be mediated by a crosstalk with OSMR.
Authors
- Matteo Pirro (ORCID: https://orcid.org/0000-0002-5527-4821)
- Elena Tremoli (ORCID: https://orcid.org/0000-0002-0929-6106)
- Bruna Gigante (ORCID: https://orcid.org/0000-0003-4508-7990)
- Gunnar Engström (ORCID: https://orcid.org/0000-0002-8618-9152)
- Lars Lind (ORCID: https://orcid.org/0000-0003-2335-8542)
- Anders Gummesson (ORCID: https://orcid.org/0000-0003-0024-960X)
- Hanna M. Björck (ORCID: https://orcid.org/0000-0002-9155-3609)
- Sudhir Kurl (ORCID: https://orcid.org/0000-0003-4598-0404)
- Per Eriksson (ORCID: https://orcid.org/0000-0002-5635-2692)
- Ljubica Matic (ORCID: https://orcid.org/0000-0002-7294-9667)
- Fabrizio Veglia (ORCID: https://orcid.org/0000-0002-9378-8874)
- Carl Johan Östgren (ORCID: https://orcid.org/0000-0003-1617-3179)
- Ulf Hedin (ORCID: https://orcid.org/0000-0001-9212-3945)
- Antonio Gallo (ORCID: https://orcid.org/0000-0002-8887-994X)
- Rona J. Strawbridge (ORCID: https://orcid.org/0000-0001-8506-3585)
- Damiano Baldassarre (ORCID: https://orcid.org/0000-0002-2766-8882)
- Douwe J. Mulder (ORCID: https://orcid.org/0000-0003-3715-6474)
- Kai Savonen (ORCID: https://orcid.org/0000-0002-6871-8153)
- Otto Bergman (ORCID: https://orcid.org/0000-0003-4323-8150)
- Qiao Sen Chen
- Stefan Söderberg
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- University Medical Center Groningen (NL)
- Karolinska University Hospital (SE)
- Inserm (FR)
- University of Groningen (NL)
- University of Eastern Finland (FI)
- Lund University (SE)
- University of Milan (IT)
- University of Perugia (IT)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Sorbonne Université (FR)
- Centro Cardiologico Monzino (IT)
- Kuopio University Hospital (FI)
- Region Västra Götaland (SE)
- Maria Cecilia Hospital (IT)
- Pitié-Salpêtrière Hospital (FR)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
- University of Glasgow (GB)
- University of Gothenburg (SE)
- Umeå University (SE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1093/cvr/cvaf177
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00