Genomic alterations and associated outcomes in patients with PSMA-positive metastatic castration-resistant prostate cancer treated with 177Lu-PSMA-617
This analysis identifies potential genomic predictors of response to 177Lu-PSMA-617, with NF1 and FOXA1 alterations associated with favorable outcomes and AR and TSG alterations with diminished response. These hypothesis-generating findings suggest genomic profiling may inform selection for PSMA-targeted therapy and warrant prospective validation in larger cohorts.
Authors
- Elisabeth I. Heath (ORCID: https://orcid.org/0000-0003-1381-2713)
- Daniel Herchenhorn (ORCID: https://orcid.org/0000-0001-5166-848X)
- Alexandra Sokolova (ORCID: https://orcid.org/0000-0003-0821-6503)
- Justine Panian (ORCID: https://orcid.org/0000-0002-6651-195X)
- Michael Thomas Schweizer (ORCID: https://orcid.org/0000-0002-5510-0661)
- Jones T. Nauseef (ORCID: https://orcid.org/0000-0003-2302-4171)
- Laura Graham (ORCID: https://orcid.org/0000-0003-4371-572X)
- Vadim S. Koshkin (ORCID: https://orcid.org/0000-0003-2277-8668)
- Andrew J. Armstrong (ORCID: https://orcid.org/0000-0001-7012-1754)
- Ajjai Alva (ORCID: https://orcid.org/0000-0002-1898-3522)
- Taylor S. Amery (ORCID: https://orcid.org/0009-0008-5007-4952)
- Clara Hwang (ORCID: https://orcid.org/0000-0002-0998-323X)
- Mehmet Asım Bilen (ORCID: https://orcid.org/0000-0003-4003-1103)
- Yousef Zakharia (ORCID: https://orcid.org/0000-0001-9480-2626)
- Pedro Coelho Barata (ORCID: https://orcid.org/0000-0002-8890-2951)
- Tanya Jindal (ORCID: https://orcid.org/0000-0001-5954-3278)
- Deepak Kilari (ORCID: https://orcid.org/0000-0002-6999-1901)
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Ruben Raychaudhuri (ORCID: https://orcid.org/0000-0001-6587-4954)
- Bicky Thapa (ORCID: https://orcid.org/0000-0002-7636-8907)
- Tanya Barauskas Dorff (ORCID: https://orcid.org/0000-0001-5990-298X)
- Zachery R. Reichert (ORCID: https://orcid.org/0000-0003-0356-8796)
- John Wang (ORCID: https://orcid.org/0000-0003-0935-9362)
- Nicholas Henderson (ORCID: https://orcid.org/0000-0003-3184-0945)
- Avery K. Supernois
Institutions
- University of Iowa (US)
- Emory University (US)
- Henry Ford Health System (US)
- University of San Diego (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Wayne State University (US)
- Medical College of Wisconsin (US)
- Cornell University (US)
- University of Michigan (US)
- University of California San Diego (US)
- Fred Hutch Cancer Center (US)
- City of Hope (US)
- Michigan Medicine (US)
- Dana-Farber Cancer Institute (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- Weill Cornell Medicine (US)
- University of Colorado Anschutz Medical Campus (US)
- University of San Francisco (US)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1093/oncolo/oyaf358
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00