Beyond the bugs: why toxin detection is key in two-tiered <i>C. diff</i> tests
Our study supports previous findings that a two-tier testing strategy effectively identifies active <i>C. diff</i> infection rather than colonization, effectively improving antibiotic stewardship efforts. Some toxin-negative patients also had colitis symptoms and responded to antibiotics, indicating that clinical judgment is still needed in cases with discrepant results.
Authors
- David Goldmeier
- Asha K. Shah
- Marija Mirković (ORCID: https://orcid.org/0000-0002-3176-5554)
- Suzanne J. Rose (ORCID: https://orcid.org/0000-0001-5770-826X)
- Michael F. Parry (ORCID: https://orcid.org/0000-0003-0341-3989)
- Shweta Karki (ORCID: https://orcid.org/0009-0000-7630-6645)
- Forugh Homayoonrooz
Institutions
- George Washington University Hospital (US)
- Stamford Hospital (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10196
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00